Cell-cell junctions · USMLE Step 1

Which type of cell junction connects intermediate filaments of adjacent cells via cadherin proteins and is prominent in tissues subject to mechanical stress (e.g., skin, myocardium)?

  1. Tight junction
  2. Adherens junction
  3. Desmosome
  4. Gap junction
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Correct answer: Desmosome

Desmosomes are anchoring junctions that link intermediate filament networks of neighboring cells via cadherin family proteins (desmoglein/desmocollin), thereby providing strong mechanical adhesion especially in stress-bearing tissues.

Difficulty: Medium Question 6 of 20

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