Screening and Diagnostic Test Validity · USMLE Step 1

Which scenario best illustrates verification bias?

  1. Only screen-positive patients receive the gold standard
  2. Study participants are lost to follow-up
  3. Test results differ across age groups
  4. Test is interpreted differently by multiple physicians
Show answer and explanation

Correct answer: Only screen-positive patients receive the gold standard

Verification bias occurs when not all subjects undergo the gold standard test. This skews estimates of sensitivity and specificity.

Difficulty: Medium Question 14 of 20

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