Screening and Diagnostic Test Validity · USMLE Step 1

In what situation would a test’s PPV increase even if sensitivity and specificity remain constant?

  1. A decrease in prevalence
  2. An increase in prevalence
  3. A larger sample size
  4. More false negatives
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Correct answer: An increase in prevalence

PPV increases as prevalence increases. This makes a positive test result more likely to represent true disease.

Difficulty: Medium Question 17 of 20

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