Screening and Diagnostic Test Validity · USMLE Step 1

A physician wants to rule out pulmonary embolism using a D-dimer test. Which feature of the test makes it useful?

  1. High specificity
  2. Low sensitivity
  3. High sensitivity
  4. Low NPV
Show answer and explanation

Correct answer: High sensitivity

D-dimer testing is highly sensitive, making it good for ruling out disease when negative. A negative result reliably excludes pulmonary embolism.

Difficulty: Medium Question 12 of 20

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