Drug Overdose Management · Pharmacology

Pyridoxine (Vitamin B6) is a specific antidote for a seizure-inducing overdose of which drug?

  1. Isoniazid
  2. Valproic acid
  3. Lithium
  4. Amiodarone
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Correct answer: Isoniazid

Isoniazid interferes with the production of GABA by inhibiting the enzyme that requires Vitamin B6 as a cofactor. Administering pyridoxine restores GABA levels and stops the resulting seizures.

Difficulty: Medium Question 17 of 20

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