Drug Overdose Management · Pharmacology

What is the mechanism of action of Digoxin Immune Fab (Digibind) in treating Digoxin toxicity?

  1. It increases renal clearance of Digoxin
  2. It stimulates the Na+/K+ ATPase pump
  3. It binds to and sequesters Digoxin in the blood
  4. It blocks the calcium channels in cardiac myocytes
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Correct answer: It binds to and sequesters Digoxin in the blood

Digoxin Immune Fab consists of antibody fragments that have a high affinity for digoxin. They bind to the drug, pulling it away from tissue sites and forming a complex that is eventually excreted by the kidneys.

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