Drug Overdose Management · Pharmacology

Which of the following is the specific antidote used for an overdose of Acetaminophen (Paracetamol)?

  1. Flumazenil (Romazicon)
  2. N-acetylcysteine
  3. Naloxone
  4. Atropine
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Correct answer: N-acetylcysteine

N-acetylcysteine acts by restoring glutathione stores in the liver. This allows for the safe detoxification of the reactive metabolite NAPQI, preventing hepatic necrosis.

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