What is the primary indication for the use of Leucovorin (Folinic Acid) in toxicology?
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Correct answer: Overdose of Methotrexate
Methotrexate inhibits dihydrofolate reductase, depleting the body of reduced folates. Leucovorin provides a source of reduced folate that bypasses the inhibited enzyme, 'rescuing' normal cells from toxicity.
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