Which term better reflects clinical safety in humans compared to the traditional therapeutic index?
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Correct answer: Therapeutic window
The therapeutic window is more clinically relevant because it refers to the plasma concentration range that is effective yet non-toxic in humans. Traditional TI is often derived from animal LD50 values, which may not directly translate to humans.
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More Therapeutic Index questions
- An increase in drug interactions that elevate plasma concentration would most significantly affect drugs with:
- Which of the following is LEAST likely to require therapeutic drug monitoring?
- The certain safety factor is calculated as:
- Which scenario would decrease the effective therapeutic index of a drug in a patient?
- In clinical practice, the therapeutic index is most relevant for drugs that:
- Which parameter indicates the median dose producing toxicity in 50% of subjects?