An increase in drug interactions that elevate plasma concentration would most significantly affect drugs with:
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Correct answer: Narrow therapeutic index
Drugs with a narrow therapeutic index are especially vulnerable to interactions that increase plasma levels. Even slight increases can result in toxicity. Therefore, co-administration of interacting drugs requires caution.
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More Therapeutic Index questions
- Which of the following is LEAST likely to require therapeutic drug monitoring?
- The certain safety factor is calculated as:
- Which scenario would decrease the effective therapeutic index of a drug in a patient?
- In clinical practice, the therapeutic index is most relevant for drugs that:
- Which parameter indicates the median dose producing toxicity in 50% of subjects?
- A drug’s therapeutic index does NOT account for: