Warfarin requires regular INR monitoring primarily because it:
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Correct answer: Has a narrow therapeutic index
Warfarin has a narrow therapeutic index, meaning that small variations in dose can lead to bleeding or thrombosis. INR monitoring ensures that the drug concentration remains within the therapeutic window. This reduces the risk of adverse outcomes.
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More Therapeutic Index questions
- A drug with a therapeutic index of 2 would be considered:
- Which term better reflects clinical safety in humans compared to the traditional therapeutic index?
- An increase in drug interactions that elevate plasma concentration would most significantly affect drugs with:
- Which of the following is LEAST likely to require therapeutic drug monitoring?
- The certain safety factor is calculated as:
- Which scenario would decrease the effective therapeutic index of a drug in a patient?