A narrow therapeutic index implies that:
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Correct answer: Small increases in dose may cause toxicity
A narrow therapeutic index indicates that the toxic dose is close to the effective dose. Even small increases in dosage or plasma concentration may lead to adverse effects. Therefore, dosing must be precise.
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More Therapeutic Index questions
- Which statistical measures are typically used to calculate therapeutic index in animal studies?
- Warfarin requires regular INR monitoring primarily because it:
- A drug with a therapeutic index of 2 would be considered:
- Which term better reflects clinical safety in humans compared to the traditional therapeutic index?
- An increase in drug interactions that elevate plasma concentration would most significantly affect drugs with:
- Which of the following is LEAST likely to require therapeutic drug monitoring?