Pharmacogenomics · Pharmacology

In pharmacogenomics, the term 'phenoconversion' refers to:

A mutation that permanently changes a person's blood type
A drug interaction that alters a patient's metabolizer phenotype
The repair of DNA damage following exposure to ionizing radiation
A change in gene expression caused by normal aging

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Correct answer: A drug interaction that alters a patient's metabolizer phenotype

Phenoconversion occurs when a patient with a 'Normal Metabolizer' genotype takes a potent enzyme inhibitor (e.g., fluoxetine inhibiting CYP2D6), making them clinically behave like a 'Poor Metabolizer'.

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