Which genetic variation is linked to an increased risk of 'Torsades de Pointes' when taking QT-prolonging drugs?
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Correct answer: Congenital long QT syndrome mutations
Mutations in cardiac ion channel genes can cause subclinical Long QT Syndrome. When these patients take drugs that further block potassium channels (like certain antiarrhythmics or antibiotics), they are at high risk for fatal arrhythmias.
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