Which TCA is the most 'noradrenergic,' meaning it has the highest selectivity for inhibiting norepinephrine reuptake over serotonin?
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Correct answer: Desipramine
Desipramine is a secondary amine TCA and is the most potent and selective inhibitor of norepinephrine reuptake in its class. In contrast, tertiary amines like amitriptyline are more balanced or serotonin-selective.
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