Antidepressants · Pharmacology

Vilazodone acts as an SSRI and also as which of the following?

  1. 5-HT1A receptor partial agonist
  2. Potent dopamine D2 receptor antagonist
  3. Alpha-1 adrenergic antagonist
  4. Norepinephrine reuptake inhibitor
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Correct answer: 5-HT1A receptor partial agonist

Vilazodone is referred to as an SPARI (Serotonin Partial Agonist and Reuptake Inhibitor). Its partial agonism at 5-HT1A receptors is thought to enhance its antidepressant effect and potentially reduce some serotonergic side effects.

Difficulty: Medium Question 19 of 20

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