Antidepressants Practice Questions
20 free Antidepressants practice questions for the Pharmacology, each with the correct answer and a detailed explanation. Open any question below, or take the full set as an interactive quiz.
Questions
20 questions
All Antidepressants questions
- Q1. Which of the following describes the primary mechanism of action of Selective Serotonin Reuptake Inhibitors (SSRIs)?
- Q2. Which antidepressant is known for its dual mechanism of inhibiting both serotonin and norepinephrine reuptake, but lacks the significant alpha-blocking and ant…
- Q3. A patient taking a Monoamine Oxidase Inhibitor (MAOI) consumes aged cheese and red wine, leading to a hypertensive crisis. This 'cheese reaction' is caused by…
- Q4. Which tricyclic antidepressant (TCA) is frequently used in the management of obsessive-compulsive disorder (OCD) due to its high selectivity for serotonin reup…
- Q5. The '3 C's'—Coma, Convulsions, and Cardiotoxicity—are classic signs of overdose for which class of antidepressants?
- Q6. Which antidepressant is associated with a lower risk of sexual dysfunction and weight gain, and is also FDA-approved for smoking cessation?
- Q7. Serotonin Syndrome is a life-threatening condition that can occur when SSRIs are combined with which of the following substances?
- Q8. Which antidepressant acts as an antagonist at presynaptic alpha-2 autoreceptors, leading to increased release of both serotonin and norepinephrine?
- Q9. Which SSRI has a half-life of about 4–6 days and an active metabolite that persists in the body for weeks?
- Q10. Which of the following is a potential side effect of Trazodone that requires immediate medical attention?
- Q11. Why are TCAs generally avoided in patients with benign prostatic hyperplasia (BPH) or narrow-angle glaucoma?
- Q12. Vortioxetine is classified as a 'serotonin modulator and stimulator' because it inhibits SERT and also acts as a:
- Q13. Which of the following antidepressants is often used at low doses as a sleep aid due to its potent H1-histamine receptor antagonism?
- Q14. Which lab parameter should be monitored in elderly patients starting an SSRI, due to the risk of SIADH?
- Q15. What is the clinical significance of the 'black box warning' on all antidepressant medications?
- Q16. Which SSRI is notorious for having the shortest half-life and the most significant withdrawal (discontinuation) symptoms?
- Q17. Selegiline is a unique MAOI because when administered via a transdermal patch at low doses, it:
- Q18. Which of the following is a common side effect of SNRIs that is not typically seen with SSRIs?
- Q19. Vilazodone acts as an SSRI and also as which of the following?
- Q20. Which TCA is the most 'noradrenergic,' meaning it has the highest selectivity for inhibiting norepinephrine reuptake over serotonin?