Which SSRI is notorious for having the shortest half-life and the most significant withdrawal (discontinuation) symptoms?
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Correct answer: Paroxetine
Paroxetine has a short half-life and no active metabolites. Abruptly stopping it can lead to 'Discontinuation Syndrome,' characterized by 'zapping' sensations, dizziness, and irritability, more so than SSRIs with longer half-lives.
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