Complete Exam Guide Subject-wise practice platform
Antidepressants · Pharmacology

Selegiline is a unique MAOI because when administered via a transdermal patch at low doses, it:

  1. Selectively inhibits MAO-A within the central nervous system
  2. Maintains its selectivity for MAO-B and avoids the 'cheese reaction'
  3. Loses its selectivity and inhibits both MAO-A and MAO-B
  4. Still requires patients to follow a strict low-tyramine diet even at low doses
Show answer and explanation

Correct answer: Maintains its selectivity for MAO-B and avoids the 'cheese reaction'

At low doses, Selegiline is selective for MAO-B. The transdermal patch delivery bypasses the gut and liver, avoiding the inhibition of GI MAO-A, which allows patients to consume normal amounts of tyramine-containing foods safely.

Difficulty: Medium Question 17 of 20

Practice all 20 Antidepressants questions

Keep practicing

More Antidepressants questions