The use of Proton Pump Inhibitors (PPIs) like Omeprazole with Clopidogrel is controversial because:
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Correct answer: PPIs may inhibit CYP2C19, reducing Clopidogrel activation
Certain PPIs (especially Omeprazole and Esomeprazole) are inhibitors of CYP2C19. Because Clopidogrel requires this enzyme for activation, concurrent use may lead to lower levels of the active antiplatelet metabolite and potentially increase the risk of cardiovascular events.
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More Antiplatelet Drugs questions
- What is the primary mechanism of action of Aspirin in inhibiting platelet aggregation?
- Which of the following antiplatelet drugs is a prodrug that requires two-step hepatic activation by CYP450 enzymes, particularly CYP2C19?
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