Why does low-dose Aspirin (81mg) exhibit selectivity for inhibiting platelet COX-1 over systemic COX-2?
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Correct answer: Platelets are anucleate and cannot replace COX-1
Since platelets are anucleated, they cannot synthesize new proteins. Once Aspirin inhibits their COX-1, the effect lasts for the platelet's lifespan. Endothelial cells, however, can synthesize new COX enzymes, allowing systemic PGI2 production to recover.
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