What is the primary mechanism of action of Aspirin in inhibiting platelet aggregation?
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Correct answer: Irreversible acetylation of the cyclooxygenase-1 (COX-1) enzyme
Aspirin irreversibly inhibits COX-1 by acetylating a serine residue near the active site. This prevents the synthesis of Thromboxane A2 (TXA2), a potent inducer of platelet aggregation, for the lifetime of the platelet.
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