Which of the following is the most common mechanism of bacterial resistance to tetracyclines?
Show answer and explanation
Correct answer: Increased efflux via active pump proteins
Resistance is primarily mediated by plasmid-encoded efflux pumps (like TetA) that actively remove the drug from the bacterial cell. Other mechanisms include ribosomal protection proteins and enzymatic inactivation.
Keep practicing
More Tetracyclines questions
- Which tetracycline derivative is preferred in patients with renal failure because it is primarily excreted via the bile and feces?
- Why are tetracyclines generally contraindicated in children under the age of 8 and during pregnancy?
- A patient taking Doxycycline for acne develops a severe sunburn-like rash after brief sun exposure. This is an example of which side effect?
- Which tetracycline is specifically used off-label to treat the Syndrome of Inappropriate Antidiuretic Hormone (SIADH) because it inhibits t…
- Tigecycline belongs to which subclass of tetracyclines designed to overcome common resistance mechanisms?
- Which of the following substances should be avoided when taking oral tetracyclines because they decrease the drug's absorption?