Tetracyclines · Pharmacology

Tigecycline belongs to which subclass of tetracyclines designed to overcome common resistance mechanisms?

  1. Glycylcyclines
  2. Fluorocyclines
  3. Aminomethylcyclines
  4. Anhydrotetracyclines
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Correct answer: Glycylcyclines

Tigecycline is a glycylcycline that has a high affinity for the ribosome and is not affected by many of the efflux pumps and ribosomal protection proteins that confer resistance to older tetracyclines.

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