Drug Resistance Mechanisms · Pharmacology

Vancomycin resistance in Enterococcus species is primarily due to:

  1. Overexpression of efflux pumps
  2. Alteration of D-Ala-D-Ala to D-Ala-D-Lac
  3. Production of extended-spectrum beta-lactamases
  4. Mutation of the 50S ribosomal subunit
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Correct answer: Alteration of D-Ala-D-Ala to D-Ala-D-Lac

Vancomycin resistance occurs when bacteria alter the target site from D-Ala-D-Ala to D-Ala-D-Lac in peptidoglycan precursors. This reduces vancomycin binding affinity.

Difficulty: Medium Question 6 of 20

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