Beta-Lactam Antibiotics · Pharmacology

A common side effect of oral Amoxicillin/Clavulanate (Augmentin) is diarrhea. This is most often caused by:

  1. Direct stimulation of motilin receptors
  2. The irritation of the gastric lining by Clavulanic acid
  3. Inhibition of acetylcholinesterase
  4. Destruction of vitamin K-producing bacteria
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Correct answer: The irritation of the gastric lining by Clavulanic acid

Clavulanic acid can stimulate gut motility and irritate the GI tract. This leads to a higher incidence of diarrhea compared to Amoxicillin alone.

Difficulty: Medium Question 12 of 20

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