Which NSAID is unique for its ability to irreversibly inhibit cyclooxygenase enzymes through acetylation?
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Correct answer: Aspirin
Aspirin (acetylsalicylic acid) covalently modifies the COX enzymes by acetylating a serine residue in the active site. Because platelets cannot synthesize new enzymes, this inhibition lasts for the entire lifespan of the platelet (7-10 days).
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