A patient with a history of peptic ulcer disease requires an anti-inflammatory for osteoarthritis. Which of the following is a selective COX-2 inhibitor that carries a lower risk of GI bleeds?
Show answer and explanation
Correct answer: Celecoxib
Celecoxib is a selective COX-2 inhibitor. By sparing the COX-1 enzyme, which is responsible for producing protective prostaglandins in the gastric mucosa, it reduces the risk of gastrointestinal ulceration compared to non-selective agents.
Keep practicing
More NSAIDs questions
- Which of the following is the primary reason why selective COX-2 inhibitors are associated with an increased risk of cardiovascular events?
- A 6-year-old child presents with viral symptoms. Why is Aspirin contraindicated in this patient?
- Which NSAID is commonly used intravenously or intramuscularly for short-term management of moderate to severe acute pain, but is limited to…
- Which of the following NSAIDs is a prodrug that is converted into its active sulfide metabolite in the liver, potentially sparing the stoma…
- NSAIDs can reduce the antihypertensive efficacy of ACE inhibitors primarily by which mechanism?
- Which condition is a classic contraindication for the use of NSAIDs due to the potential for 'triad' exacerbation (Samter's Triad)?