How do the E6 and E7 oncoproteins of High-risk HPV (Types 16 and 18) contribute to carcinogenesis?
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Correct answer: E6 inhibits p53, and E7 inhibits RB
High-risk HPV oncoproteins target tumor suppressor proteins: E6 binds to and facilitates the degradation of p53, while E7 binds to RB and releases the E2F transcription factor, promoting cell cycle progression into the S-phase.
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