What is the function of the APC (Adenomatous Polyposis Coli) gene in the WNT signaling pathway?
Show answer and explanation
Correct answer: It is part of a complex that degrades beta-catenin
APC is a 'Gatekeeper' tumor suppressor. In the absence of WNT signals, APC helps degrade beta-catenin; loss of APC allows beta-catenin to accumulate and move to the nucleus, where it activates growth-promoting genes.
Keep practicing
More Carcinogenesis questions
- Ultraviolet (UVB) radiation causes carcinogenesis primarily through which mechanism?
- Which of the following describes the 'Warburg Effect' in cancer cells?
- Aflatoxin B1, produced by the fungus Aspergillus flavus, is a potent carcinogen for which organ?
- The Philadelphia chromosome, t(9;22), creates a fusion gene that encodes a constitutively active:
- In the process of metastasis, which molecule do tumor cells typically downregulate to detach from neighboring cells?
- Which of the following is an example of an 'Oncogenic RNA Virus'?