The Philadelphia chromosome, t(9;22), creates a fusion gene that encodes a constitutively active:
Show answer and explanation
Correct answer: Tyrosine kinase
The t(9;22) translocation fuses the BCR and ABL genes. The resulting BCR-ABL protein is a mutant tyrosine kinase that is always active, driving the uncontrolled proliferation of myeloid cells in Chronic Myeloid Leukemia (CML).
Keep practicing
More Carcinogenesis questions
- In the process of metastasis, which molecule do tumor cells typically downregulate to detach from neighboring cells?
- Which of the following is an example of an 'Oncogenic RNA Virus'?
- Which DNA repair deficiency is associated with a high risk of skin cancer due to the inability to repair UV-induced damage?
- What is the role of 'Angiogenesis' in tumor growth?
- Which of the following describes the 'Initiation' stage of chemical carcinogenesis?
- The 'Two-Hit Hypothesis' by Knudson is most famously associated with the development of which tumor?