Viral Infections · Pathology

What is the molecular mechanism behind 'Antigenic Shift' in Influenza A viruses?

  1. Serial accumulation of point mutations in hemagglutinin and neuraminidase genes
  2. Reassortment of genomic RNA segments between two co-infecting viral strains
  3. Direct horizontal gene transfer from non-human bacterial reservoir hosts
  4. Splicing of the viral DNA into the host genome via an integrase enzyme
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Correct answer: Reassortment of genomic RNA segments between two co-infecting viral strains

Antigenic shift occurs when a single host is infected with two different strains of Influenza A, leading to the exchange of entire RNA segments. This results in a major change in viral surface proteins, often triggering pandemics.

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