Viral Infections · Pathology

Which viral infection is associated with the formation of 'Guarnieri bodies' in the cytoplasm of epithelial cells?

  1. Varicella
  2. Variola (Smallpox)
  3. Herpes Simplex (HSV-1)
  4. Rhinovirus (Picornavirus)
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Correct answer: Variola (Smallpox)

Poxviruses, like Smallpox, replicate in the cytoplasm rather than the nucleus. Guarnieri bodies are B-type inclusions that serve as 'viral factories' where viral assembly occurs.

Difficulty: Medium Question 12 of 20

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