Viral Infections · Pathology

What is the typical histological appearance of the brain in Rabies after several days of symptoms?

  1. Extensive periventricular white matter demyelination
  2. Perivascular lymphocytic cuffing and microglial nodules
  3. Large confluent areas of liquefactive cortical necrosis
  4. Spongiform encephalopathy with cortical neuron vacuolation
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Correct answer: Perivascular lymphocytic cuffing and microglial nodules

While Negri bodies are specific, the general pattern of Rabies (and many other viral encephalitides) includes perivascular cuffing (lymphocytes surrounding blood vessels) and the formation of Babes nodes (microglial nodules).

Difficulty: Medium Question 16 of 20

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