Which tumor is most strongly associated with Human T-cell Lymphotropic Virus-1 (HTLV-1)?
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Correct answer: Adult T-cell Leukemia/Lymphoma
HTLV-1 is a retrovirus that infects CD4+ T-cells. It encodes the Tax protein, which activates cell growth pathways and inhibits DNA repair, eventually leading to ATLL in a small percentage of infected individuals.
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