Which condition is associated with a 'failure' or inhibition of normal apoptosis?
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Correct answer: Follicular lymphoma
Follicular lymphoma is often caused by a translocation that overexpresses the Bcl-2 gene, which inhibits apoptosis. Conversely, neurodegenerative diseases like Alzheimer's are characterized by excessive or inappropriate apoptosis.
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More Apoptosis and Its Significance questions
- What is the role of IAPs (Inhibitor of Apoptosis Proteins) in the cell?
- Which of the following triggers would most likely activate the intrinsic apoptotic pathway?
- The cleavage of which structural protein by caspases leads to the characteristic 'blebbing' of the plasma membrane?
- What is the biological significance of apoptosis in the context of viral infections?
- Which of the following describes the morphological hallmark of apoptosis that distinguishes it from necrosis?
- The 'intrinsic pathway' of apoptosis is primarily regulated by which organelle?