Apoptosis and Its Significance · NCERT Biology

Which of the following describes the morphological hallmark of apoptosis that distinguishes it from necrosis?

  1. Cellular swelling followed by plasma membrane lysis
  2. Pro-inflammatory signaling in the surrounding tissue
  3. Cytoplasmic shrinkage and chromatin condensation
  4. Random fragmentation of DNA into variable-length pieces
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Correct answer: Cytoplasmic shrinkage and chromatin condensation

Apoptosis is characterized by cell shrinkage and the condensation of chromatin (pyknosis), which keeps the cellular contents contained. Unlike necrosis, this process does not involve membrane rupture or the release of inflammatory signals into the extracellular space.

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