Neurophysiology and Synapses · USMLE Step 1

In a neuron, where is the resting membrane potential typically established, and what primarily maintains it?

At the synapse, maintained by ligand-gated ion channels
At the dendrites, maintained by neurotransmitter binding
Across the membrane, set by the Na⁺/K⁺-ATPase and selective ion permeability
At the axon terminal, maintained by calcium ion pumps

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Correct answer: Across the membrane, set by the Na⁺/K⁺-ATPase and selective ion permeability

The resting membrane potential is established across the entire neuronal membrane and is primarily maintained by the Na⁺/K⁺-ATPase pump and selective permeability to ions like K⁺.

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In a neuron, where is the resting membrane potential typically established, and what primarily maintains it?

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