Neurophysiology and Synapses · USMLE Step 1

In the event of decreased extracellular calcium concentration, which of the following synaptic processes would be most impaired?

  1. Neurotransmitter binding to postsynaptic receptors
  2. Synthesis of neurotransmitter within vesicles
  3. Vesicle fusion and neurotransmitter release
  4. Reuptake of neurotransmitter by glial cells
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Correct answer: Vesicle fusion and neurotransmitter release

Calcium influx into the presynaptic terminal is critical for triggering vesicle fusion and neurotransmitter release; reduced extracellular calcium would impair this release phase.

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