Neurophysiology and Synapses · USMLE Step 1

Which of the following best explains why some synapses produce long-term increases in strength (LTP) rather than just transient postsynaptic potentials?

  1. Permanent opening of postsynaptic ion channels with neurotransmitter always bound
  2. Synaptic remodeling that alters ion channel number or function
  3. Sustained high-frequency postsynaptic action potentials
  4. Indefinite failure of neurotransmitter reuptake mechanisms
Show answer and explanation

Correct answer: Synaptic remodeling that alters ion channel number or function

Long-term potentiation (LTP) and other plastic changes are mediated by molecular and structural modifications at the synapse – for instance, altering ion channel expression or conductance – thereby changing synaptic strength.

Difficulty: Medium Question 27 of 28

Practice all 28 Neurophysiology and Synapses questions

Keep practicing

More Neurophysiology and Synapses questions