Neurophysiology and Synapses · USMLE Step 1

Which of the following processes is most directly involved in the phenomenon of synaptic plasticity underlying learning and memory?

  1. Changes in synaptic cleft width over time
  2. Modulation of ion channel expression or function at synapses
  3. Continuous release of neurotransmitter irrespective of action potentials
  4. Permanent opening of all postsynaptic receptors
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Correct answer: Modulation of ion channel expression or function at synapses

Synaptic plasticity — such as long-term potentiation/depression — often involves changes in the number or properties of ion channels at the synapse, thereby modulating synaptic strength.

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