Neuro-pharmacology · USMLE Step 1

A patient with schizophrenia begins haloperidol therapy. Within days, he develops severe muscle stiffness and neck rigidity. Which adverse effect is most likely responsible?

  1. Tardive dyskinesia
  2. Acute dystonia
  3. Akathisia
  4. Neuroleptic malignant syndrome
Show answer and explanation

Correct answer: Acute dystonia

Acute dystonia is an early extrapyramidal effect of antipsychotics, presenting with sudden muscle spasms and rigidity.

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