Neuro-pharmacology · USMLE Step 1

A patient with epilepsy begins valproate therapy. Which serious adverse effect requires monitoring?

  1. Renal failure
  2. Hepatotoxicity
  3. Hypothyroidism
  4. Cardiomyopathy
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Correct answer: Hepatotoxicity

Valproate can cause fatal hepatotoxicity, particularly in children, requiring liver function monitoring.

Difficulty: Medium Question 7 of 20

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