Neuro-pharmacology · USMLE Step 1

A woman is prescribed fluoxetine for major depression. She is also taking a MAO inhibitor. What is the major risk of combining these medications?

  1. Sedation
  2. Serotonin syndrome
  3. Neuroleptic malignant syndrome
  4. Tardive dyskinesia
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Correct answer: Serotonin syndrome

Combining SSRIs with MAOIs causes excess serotonin, leading to life-threatening serotonin syndrome.

Difficulty: Medium Question 3 of 20

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