Neuro-pharmacology · USMLE Step 1

A patient taking MAO inhibitors experiences hypertension after eating cheese and wine. What causes this reaction?

  1. Excess histamine release
  2. Sudden dopamine release
  3. Tyramine catecholamine surge
  4. Relative serotonin deficiency
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Correct answer: Tyramine catecholamine surge

Tyramine promotes catecholamine release, and MAO inhibition prevents its metabolism, causing hypertensive crisis.

Difficulty: Medium Question 15 of 20

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