Neuro-pharmacology · USMLE Step 1

A woman taking topiramate for seizures develops kidney stones. What mechanism contributes to this?

  1. Increased uric acid reabsorption
  2. Carbonic anhydrase inhibition
  3. Hyperparathyroidism
  4. Oxalate accumulation
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Correct answer: Carbonic anhydrase inhibition

Topiramate inhibits carbonic anhydrase, leading to metabolic acidosis and increased risk of kidney stones.

Difficulty: Medium Question 14 of 20

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