Neuro-pharmacology · USMLE Step 1

A man with opioid addiction begins methadone maintenance therapy. Which property makes methadone effective?

  1. Short half-life
  2. Partial agonism
  3. Long half-life
  4. Weak receptor affinity
Show answer and explanation

Correct answer: Long half-life

Methadone’s long half-life prevents withdrawal and stabilizes opioid levels.

Difficulty: Medium Question 19 of 20

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