Systemic Pathology by Organ · USMLE Step 1

Which of the following findings in the liver is characteristic of alcoholic fatty liver disease in early stages?

  1. Extensive bridging fibrosis and nodular cirrhosis
  2. Macrovesicular steatosis with pale hepatocytes
  3. Multiple blood-filled vascular spaces (peliosis)
  4. Marked iron deposition within hepatocytes
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Correct answer: Macrovesicular steatosis with pale hepatocytes

Alcoholic fatty liver disease begins with macrovesicular steatosis — fat accumulation giving pale, enlarged hepatocytes; fibrosis and cirrhosis develop later.

Difficulty: Medium Question 19 of 19

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