In histopathological grading of tumors, what does a high-grade tumor generally imply compared to a low-grade tumor?
Show answer and explanation
Correct answer: Poor differentiation, high mitotic rate, aggressive behavior
High-grade tumors show poor differentiation (anaplasia), high mitotic rate, and aggressive behavior, correlating with worse prognosis compared to low-grade, well-differentiated tumors.
Keep practicing
More Neoplasia and Cancer Biology questions
- Which of the following is most likely to be a paraneoplastic syndrome rather than a direct effect of tumor mass or metastasis?
- What is the defining feature that distinguishes a neoplasm from normal hyperplasia or metaplasia?
- Which of the following best differentiates benign tumors from malignant neoplasms on gross and microscopic pathology?
- Which statement about the genetic basis of cancer is most accurate?
- An activating point mutation in a proto-oncogene converts it into an oncogene. What is the usual effect of this change?
- Which hallmark of cancer reflects a tumor’s ability to stimulate formation of blood vessels to support its growth?