In chronic organ injury, why does persistent inflammation often lead to fibrosis instead of tissue regeneration?
Show answer and explanation
Correct answer: Myofibroblasts deposit excess matrix while parenchymal cells cannot regenerate
Chronic inflammation often activates myofibroblasts, leading to excess ECM deposition replacing functional tissue, resulting in fibrotic scarring rather than normal regeneration.
Keep practicing
More End-Organ Damage Mechanisms questions
- Which mechanism contributes to kidney damage in hypertension before overt renal failure develops?
- In left ventricular hypertrophy due to chronic hypertension, which structural change impairs diastolic filling and contributes to heart fai…
- How does chronic hyperglycemia in diabetes accelerate atherosclerosis and macrovascular end-organ damage?
- Which pathophysiologic mechanism underlies organ damage in ischemia-reperfusion injury (e.g., after transient vessel occlusion and reperfus…
- Which factor influences whether tissue injury heals by regeneration or progresses to fibrosis and permanent organ damage?
- Why does atherosclerotic plaque calcification contribute to further end-organ damage even without thrombosis?